It travels from the Chattahoochee River at Georgetown to its eastern end, southwest of Brunswick.

It travels through such cities as Cuthbert, Dawson, Albany, Sylvester, Tifton, Pearson, Waycross, and Nahunta.

Just past Graves, SR 45 begins a concurrency until the three routes enter Dawson.

At the intersection with US 19/SR 3, which join the concurrency, US 19 Business/US 82 Business/SR 520 Business head south into downtown Albany.

Southeast of Waycross is SR 177, which leads to Laura S. Walker State Park and the Okefenokee Swamp.

[4][5][6] The roadway that would eventually become US 82 was established at least as early as 1919 as SR 32 from Dawson through Albany and into Sylvester.

The crossing of the Altamaha River between Jesup and Ludowici was indicated to have "no bridge or ferry".

Two segments of SR 50 had a "completed hard surface": the eastern part of Albany and west-northwest of Sylvester.

Three portions of SR 50 and two segments of SR 38 had a "sand clay or top soil" surface: from Dawson to a point northwest of Albany, west-northwest of Pearson, west of Nahunta, from Blackshear to a point southwest of Jesup, and the western half of the Hinesville–Midway segment.

[8][9] By the end of 1929, three segments of SR 50 and one segment of SR 38 had a completed hard surface: the southeast part of Georgetown, from Dawson to a point northwest of Albany, from west-northwest of Waycross into the city, and from Waycross to Blackshear.

The segment of SR 38 from Jesup to Ludowici had a completed semi hard surface.

Three segments of SR 50 and two segments of SR 38 had a sand clay or top soil surface: southeast of Georgetown, from Cuthbert to Dawson, from west of Nahunta to east-northeast of that city, from about Patterson to about Screven, and from Hinesville to Midway.

The western half of the Dougherty County portion of the Dawson–Albany segment of SR 50 had a completed semi hard surface.

[10][11] By the end of the year, the portion of SR 50 straddling the Lee–Dougherty county line had a completed semi hard surface.

One segment each of both highways were indicated to be under construction: a portion west-northwest of Cuthbert and from Blackshear to northeast of the Pierce–Wayne county line.

[14][15] In August, one portion of each highway was indicated to be under construction: from Pearson to east-southeast of the Atkinson–Ware county line and nearly the entire Hinesville–Midway segment.

[22][23] In March 1934, the Ware County portion of the Pearson–Waycross segment of SR 50 had a completed hard surface.

[25][26] By the middle of 1935, nearly the entire Randolph County portion of the Cuthbert–Dawson segment had a completed hard surface.

[27][28] By the middle of the next year, a portion east-southeast of the Atkinson–Ware county line had completed grading, but was not surfaced.

[30][31] By the middle of 1937, all of SR 50 between Cuthbert and a point east-southeast of the Berrien–Atkinson county line had a completed hard surface.

From a point southeast of Georgetown to just east of the Quitman–Randolph county line, it had completed grading, but was not surfaced.

[32][33] By October, the entire Quitman County portion had a completed hard surface.

[37][38] Between February 1948 and April 1949, US 82 was designated on SR 50 from the Alabama state line to Waycross.

[2][3] By August 1950, SR 50 was extended southeast to a point just west of Jekyll Island.

[41][42] Between June 1955 and July 1957, US 17/SR 25's path northeast of the US 84/SR 50 west of Brunswick was shifted south onto US 84/SR 50.

[49][50] The next year, the bypass in Albany was built as a freeway, but there was no indication as to what highways were designated on it.