The route travels northwest, through Nankin and by Fearnside Lake, to Quitman.

There, it has an intersection with US 221/SR 76 (Greenville Highway) in the southern part of the city.

The three routes form a concurrency into downtown Quitman, where they intersect US 84/SR 38 (Screven Street).

At Washington Street, SR 76/SR 333 turn left off of the concurrency and travel into the northern part of the city, where SR 76 departs to the east onto Courtland Avenue.

Then, SR 333 continues to the north-northwest, passing by Brooks County High School and Crevasse Pond.