Starting at the Florida line south of Quitman in Brooks County,[2] SR 76 heads north concurrent with U.S. Route 221 (US 221).

In downtown Quitman, US 221 heads east, and SR 76/SR 333 stays concurrent.

It then passes through the towns of Morven and Barney before entering Cook County.

They split east of Adel, and SR 76 heads northeast into Berrien County.

[5][6] The only portion of SR 76 that is part of the National Highway System, a system of routes determined to be the most important for the nation's economy, mobility, and defense, is the concurrency with US 84/SR 38 (on US 221/SR 333) in Quitman.