Germicidins are a groups of natural products arising from Streptomyces species that acts as autoregulatory inhibitor of spore germination.

Inhibitory effects on germination are also observed when germicidin from Streptomyces is applied to Lepidium sativum.

[2] Germicidins and other natural products present potential use as pharmaceuticals, and in this case, those with possible antibiotic or antifungal activity.

With either isobutyryl-CoA or 2-methylbutyryl-CoA FabH facilitates decarboxylative condensation with malonyl-AcpP to generate an acyl-AcpP intermediate.

The acyl intermediate is then condensed and cyclized with either methylmalonyl-CoA or ethylmalonyl-CoA by Gcs to produce germicidin.