Taking place after the events of the 2016 film, the game features four-player cooperative gameplay where players control new Ghostbusters characters to defeat enemy ghosts.

After finding and battling Rampage, the gang capture him and later get a call from a ship cruise manager named Morgan who reveals that a ghost of former singer, Ruby d'Amore, has come back from the dead and needs to be caught.

"[19] Polygon's Justin McElroy argued that the PS4 version was "the most gruelingly insipid dual-stick shooter" he had ever reviewed, lacking variety insofar that it was a "perfect prison of monotony from which no fun could ever escape."

"[15] GameSpot was similarly critical of the same PS4 version, noting a lack of variety in gameplay, environments and enemy design, but did praise the soundtrack for "[evoking] the proper nostalgia".

GameSpot felt that the previous Sanctum of Slime game was marginally better, and concluded that "Ghostbusters has rare moments when it doesn't feel like an utter waste of time.