John Tobias, Phillip Hester, Evan Dorkin and Howard Bender were among the pencilers for the series.

The series went on hiatus for a time due to the publisher's financial difficulties, but was subsequently re-launched.

Each issue contained three to four comic stories, a prose story alternating from a regular tale to one narrated by Winston Zeddemore, a prose entry of Egon Spengler’s Spirit Guide typically discussing the entities in the comic, a bio of a character or ghost that appeared in the series, and a short Slimer strip.

The comics featured a rotating line-up of creators, including John Carnell, Dan Abnett, Andy Lanning, Brian Williamson, Anthony Williams, Stuart Place, Richard Starkings, and Helen Stone.

Outside of the ongoing title, the Ghostbusters were also featured in the 30 issue[15][16][17] run of The Marvel Bumper Comic.

An anthology style comic that was published by Marvel UK from 1988–1989, and that featured strips based on different characters and properties.