She was played by Annie Potts in the first two movies, and in The Real Ghostbusters, she was voiced initially by Laura Summer and later on by Kath Soucie.

Once the company's workload starts to grow, she remarks at one point that she has been working for two weeks straight without a break and says sourly, "I've quit better jobs than this."

After the battle with Gozer, she is seen outside of 55 Central Park West, hugging Egon, happy to see him alive and well, joining the rest of the Ghostbusters as they drive off in the Ecto-1.

Though her parents, sister, nephew, and grandmother all live in Canarsie (as seen in "Janine's Day Off"), she has remained in Brooklyn Heights, where she grew up.

In 1987, Janine owns a red Volkswagen Beetle convertible, which is severely damaged after being loaned to the Ghostbusters in "Beneath These Streets".

She has a sharp, sarcastic sense of humor and has been known to make jokes about the Ghostbusters, either to their faces or under her breath, but most of the time, she usually gets along with Ray and Winston while usually having a kind of sibling rivalry with Peter.

Unknown to Janine, the demon was feeding on her desire to be "perfect" for Egon to slowly strip away her humanity and turn her into a "makeoveris lotsabucks" herself.

In the climax of the episode, Janine turns into a "makeoverus lotsabucks" with powers similar to those of her "fairy godmother" (allowing her to change her own appearance at will).

Egon defeats the demon's hold over Janine by confessing his love for her (the NOW and Marvel UK comics ignore these changes).

At some point prior to the film, she dyed her hair red (to match the appearance of the animated iteration of the character from The Real Ghostbusters), Peter Venkman assigns her to babysit Dana Barrett's baby, Oscar.

Having been recently downsized from her last job, she returned to school at the New York City College, and among the various (and unmentioned) courses she is taking is a paranormal one, where she is reunited with Egon, going on to help him form the new team.

[3] In the film, now an elderly woman, Janine informs Egon's daughter, Callie, of her father's death and her inheritance of his decrepit farm in Summerville, Oklahoma.

In the film, Janine returned being a receptionist to the Ghostbusters and serves as a liaison between them and Zeddemore Industries's paranormal research and development center.

Annie Potts reprised her role as Janine in Ghostbusters: The Video Game, once again being the team's secretary, warning them about what's going on, either by calling them or by radio, and making sarcastic comments about the situation.

[4] Janine appears as a non-playable character in the Ghostbusters Adventure World of Lego Dimensions, voiced by Courtenay Taylor.