The product line focuses on the Ghostbusters characters who start a ghost-catching business in New York City.

[14][15] Lego Ghostbusters began with the release of a user-designed construction set based on the Ectomobile (or Ecto-1), the vehicle that features in the films.

The design was submitted to Lego Ideas by Australian video game artist Brent Waller.

It was chosen for having "broad worldwide appeal and the fact that the model lends itself to challenging and creative building for both children and adult fans".

The Lego construction toy range is based on the film franchise and developed in collaboration with Sony Pictures Consumer Products.

The construction sets were designed to recreate the story and characters of the film series in Lego form.

[18][19] The set included Lego minifigures of Dr. Peter Venkman, Dr. Egon Spengler and Winston Zeddemore.

[41][42][43][44] The set included Lego minifigures of Abby Yates, Erin Gilbert, Jillian Holtzmann, Patty Tolan, Kevin and along with Mayhem ghost figure.

It is crammed full of authentic features and easter eggs that I’m excited for builders to discover as they put this model together.”[54] Peter Venkman & Slimer (set number: 41622)[55][56][57] was released on 1 July 2018 as part of the Lego BrickHeadz theme and based on the original 1984 Ghostbusters film.

[61] The crossover toys-to-life game Lego Dimensions (2015)[62][63][64] developed by Traveller's Tales features content based on both the original Ghostbusters and its 2016 remake.

[77] The crossover online game Lego Legacy: Heroes Unboxed (2020), developed by Gameloft[78][79] and released exclusively for Microsoft Windows, Android and iOS devices on 27 February 2020,[80][81][82] includes Peter Venkman,[83] Ray Stanz,[84] Egon Spengler, Winston Zeddemore and Slimer[85] as playable characters.