2804224139ENSG00000173230ENSMUSG00000034243Q14789n/aNM_001366283NM_001366284NM_001389631NM_030035NP_001353212NP_001353213n/aGiantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene.

[5][6][7] Giantin is located at the cis-medial rims of the Golgi apparatus and is part of the Golgi matrix that is responsible for membrane trafficking in secretory pathway of proteins.

Recent animal model knockout studies of GOLGB1 in mice,[8] rat,[9] and zebrafish[10] have shown that phenotypes are different between species ranging from mild to severe craniofacial defects in the rodent models to just minor size defects in zebrafish.

GOLGB1 protein has been shown to interact with ACBD3 and with PLK3[12] and vesicle tethering small GTPases Rab1 and Rab6.

Loss-of function studies of giantin have also suggested a role in primary cilia[15][16] function and defective regulation of glycosyltransferase expression and calcineurin signalling in tissue culture cells.