In the 1920s and 30s in Turin, he associated with a wide circle of intellectuals and artists which included architects, painters and art critics, including Giuseppe Pagano, Edoardo Persico, Felice Casorati, Gigi Chessa, Henry Paolucci, Umberto Cuzzi, Domenico Morelli, Mario Passanti, and Carlo Mollino.

His collaboration with Giuseppe Pagano, a classmate who was six years older, marks the beginning of his career as an architect, with projects that place him among the first and most important representatives of the rationalist movement in Italy.

After Jews were banned from university posts and the practice of medicine, he helped his sister assemble a secret laboratory in her bedroom at their parents' house in Turin so she could continue her medical research.

After the end of the Second World War he returned to Turin, and in 1946 joined the Giuseppe Pagano Group and the local branch of APAO, engaging with issues of postwar reconstruction and new tasks of architecture.

He focused on higher education and increasing participation in competitions for major works, including (in collaboration with colleagues Domenico Morelli, Felice Bardelli and Sergio Hutter) the project for a new building for the University of Turin.