[2] Having left single-seaters following 2004, Sernagiotto raced in Ferrari Challenge, where he won the 2006 World Finals and the 2009 Trofeo Pirelli in the Italian Series.

[6] After a brief spell in V de V Challenge Endurance where he drove with Lacorte and Enrique Bernoldi, Sernagiotto joined Villorba Corse to race in the LMP3 class of the 2015 European Le Mans Series to begin Lacorte's "Road to Le Mans" project.

[21][22] In early 2019 it was announced that Sernagiotto was going to make his full season debut in the FIA World Endurance Championship, staying with Cetilar Racing.

[25] Returning to WEC for the 2021 season, Sernagiotto took his first win in the championship at the 2021 8 Hours of Portimão and finished fifth in the LMGTE Am standings.

In early 2023, Sernagiotto joined Alessandro Cozzi at AF Corse for the 2023 International GT Open season in the Am class.

[36][37] On December 21, 2023 Cetilar Racing announced that Sernagiotto will re-join Roberto Lacorte and Antonio Fuoco in that year's Endurance Cup rounds of the 2024 IMSA SportsCar Championship.

[38] Sernagiotto scored his second podium in IMSA by finishing second in the Sebring 12 Hours, ending the season 10th in the Endurance Cup.