Glomerulonephrosis

Glomerulonephrosis is a non-inflammatory disease of the kidney (nephrosis) presenting primarily in the glomerulus (a glomerulopathy) as nephrotic syndrome.

The primary sign of glomerulonephrosis is proteinuria,[2] the loss of greater than 3.5g of protein in one day, and this can cause the urine to be visibly foamy.

[citation needed] Other forms of secondary glomerulonephrosis can be caused by autoimmune disorders such as HIV, Sjögren's Syndrome, and hepatitis B, and some cancers, including multiple myeloma.

Decreased pressure will cause water and electrolytes to move into the surrounding interstitium, the space that separates internal structures of the body and skin, leading to swelling (peripheral edema).

The leakage of water into peripheral structures decreases the total fluid volume in circulation, which will activate the Renin-Angiotensin-Aldosterone system.

[citation needed] Due to its close connection with other diseases and disorders, glomerulonephrosis is rarely diagnosed independently and is superseded by those other conditions.

This is a key step in differentiating glomerulonephrosis from conditions that also cause proteinuria, such as multiple myeloma and diabetes mellitus, that are not marked by hypoalbuminemia.

Creatinine is a byproduct of creatine metabolism that will be released as waste in urine, so it is a good benchmark for estimating how much fluid is being filtered through the glomerulus.

Individuals may also need to undergo medical nutrition therapy to make dietary changes and counteract the loss of protein.

[citation needed] Depending on the cause/type of glomerulonephrosis, especially in the case of secondary forms, there may be an array of treatments that may be required and some may be untreatable.

If left untreated completely, glomerulonephrosis will almost always develop into nephrotic syndrome and eventually kidney failure within months.

[18] Due to the connection between glomerulonephrosis and other renal conditions, and its presentation as nephrotic syndrome, a majority of the research is focused on these other causes and the effects of drugs.

[19] Studies such as this allow for improved clinical practices in renal patients and help physicians make informed decision on the combinations of medications used to prevent glomerulonephrosis.