Glycoside hydrolase family 5

A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.

[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

[8] The microbial degradation of cellulose and xylans requires several types of enzymes.

Fungi and bacteria produces a spectrum of cellulolytic enzymes (cellulases) and xylanases which, on the basis of sequence similarities, can be classified into families.

In a recent study using Molecular Dynamics simulations, a considerable correlation between thermal stability and structural rigidity of members of family 5 with solved structures has been proved.