Its genesis dates back to 1 October 1917, with the title of "Sindh National Arts College Hyderabad" having been contemplated by the International Theosophical Society.
The crucial role in running the International Theosophical Society was played by its second president, Dr. Annie Besant, a well-known educationist, orator, political and social figure of the undivided Indian sub-continent.
Since there was no college in Hyderabad Sindh, the students who wanted to continue higher education had to go to far off cities like Bombay.
The people of Hyderabad Sindh gave a large sum of money, estimated to be over Rs.
Dr. Wood, within five weeks, purchased all necessary furniture, books, equipment, etc., and hired the staff to run the institute.
Seth Pertab Rai Manghar Singh and a few others contributed their best piece of 64 acres of cultivated land for this beautiful deed.
Its faculty and other staff migrated from Hyderabad to other parts of India, leaving the institute deserted.
The deserted D. G. National College Hyderabad, because of this voluntary departure of its original owners, was taken over by the Government of Sindh.
The demand towards the up-gradation as University touched its peak when one of its shining stars, Raja Pervez Ashraf, occupied the highest seat of Prime Minister of Islamic Republic of Pakistan.
A delegation of alumni consisting of Prof. Dr. Nasiruddin Shaikh, Prof. Muhammad Idris Khan, Mr. Abdul Rehman Rajput (Ex MPA), Mr. Mazharul Haq Siddiqui (Ex VC, Sindh University), Mr. Kazi Asad Abid (renowned Journalist), met with Excellency Syed Murad Ali Shah, Chief Minister, Sindh.
The delegation briefed the Excellency CM about the outstanding contribution of their alma mater in nation-building and services being rendered for almost a century.
The representative reiterated the Alumni demand for the up-gradation of Government College Hyderabad to a university.
The official notification of Prof. Dr. Nasiruddin Shaikh (Principal, Government College Hyderabad) as acting vice chancellor on 13 February 2019.
The Chief Minister of Sindh, Syed Murad Ali Shah appointed Prof. Dr. Tayyaba Zarif as the first regular Vice Chancellor of GC University Hyderabad after the recommendations from search committee.
The faculty of science was upgraded to the degree classes in March 1951 as the number of students wishing to seek admission in B.Sc.
Ever since 1948, the college continues to occupy unique positions as a premier institution of the province of Sindh, the students of this college have been achieving enviable position in various examination conducted by the board of intermediate and secondary education, Hyderabad and the University of Sindh.
A glimpse of the honours list placed in the assembly hall bearers testimony to this claim likewise, our students continue to win a large number of prizes and trophies in the field of extra-curricular activities.