As a result of a $42 million renovation and expansion from 2003–2005, the Grand Wayne now encompasses 225,000 square feet (20,900 m2).

[1] Located on the first floor, the central convention hall of the Grand Wayne consists of 50,000 square feet (4,600 m2) in addition to the Anthony Wayne Ballroom, which consists of 10,000 square feet (930 m2).

[2] The Grand Wayne Center's north and south façades feature 1,830 floor-to-ceiling exterior windowpanes with two exterior waterfalls, at the intersections of West Jefferson and West Washington Boulevards with Harrison Street.

A nine-floor, 244-room attached Hilton Hotel operates at the east wing of the Grand Wayne Center.

[4] Also a six-floor, 250 Room Courtyard by Marriott attached via a pedestrian bridge operates just south of the main entrance to the Grand Wayne Center.