The first class of freshmen entered in September 1959, including students from as far east as Ligonier and as far west as Trafford and Charleroi.

Bishop Hugh L. Lamb dedicated the building on November 29, 1959, before an audience of 2,000, which included Governor David L. Lawrence as the featured speaker.

In 1962, Bishop William G. Connare proposed building a faculty house for all six religious groups, featuring a wing for each community with a common chapel (the Chapel of the Immaculate Heart of Mary), dining room, and community room.

The school built a stadium in 1989 and installed lights in 1998 for night football and soccer games.

The athletics program at Greensburg Central Catholic is one of the most successful in the state of Pennsylvania.