It is located within the Greenslopes suburb, on a ridge leading east from Stephens Mountain, a low hill still covered in scrub and overlooking Norman Creek to the west.

The hospital, surrounded by quiet streets, lies some distance from the nearest main roads, a factor which has caused friction with local residents over traffic, parking and redevelopment issues in recent years.

In the early 1990s the Commonwealth Government decided to move to be a purchaser of medical services rather than a provider.

Ramsay Health Care assumed responsibility for Greenslopes Hospital on 6 January 1995.

"Over time, the number of war veterans and widows needing care at the Hospital will decline as age takes its toll.