The tenth season of the American television medical drama Grey's Anatomy premiered on September 26, 2013, with a two-hour special episode in the United States on the American Broadcasting Company (ABC), and it concluded with a Farewell To Cristina finale episode "Fear (Of The Unknown)" on May 15, 2014.

Derek Shepherd (Patrick Dempsey) and Callie Torres (Sara Ramirez), having separated from her wife Arizona Robbins (Jessica Capshaw), teamed up with the White House to work on a brain mapping project.

Yang and Owen Hunt (Kevin McKidd) gradually take their relationship from complicated and painful to a place of real friendship.

She bids her farewell to her colleagues of the last 8 years, including Hunt and dances it out with Meredith one last time to an old favorite song.

In the first universe, the patient decides that he wants to be taken off the ventilator which sends Cristina into Owen’s arms when she realizes that they are throwing away their love for each other.

Time is quickly passing as the two get married, move in together, get a dog, have a baby, await the birth of their second child, and see Ross win the Harper Avery Award for Cristina's trial that she quit on to take care of her family.

They continue to have their on-again, off-again relationship which drives Owen to drinking more than he should, putting himself and his patients in grave danger.

[29] In May 2012, it was announced that 6 original castmates - Ellen Pompeo, Sandra Oh, Justin Chambers, Chandra Wilson, James Pickens, Jr. and Patrick Dempsey had renewed their contracts through season 10, as Meredith Grey, Cristina Yang, Alex Karev, Miranda Bailey, Richard Webber and Derek Shepherd respectively.

[30] It was revealed in June 2013, that 4 out of the 5 interns from Season 9 would be returning as series-regulars, including Camilla Luddington, Gaius Charles, Jerrika Hinton and Tessa Ferrer.

[31] It was announced in July 2013 that Bobby Campo and Heather Hemmens were slated to guest star in the 2-part season premiere.

[34][35] In October 2013, it was announced that Hector Elizondo would be returning to the show, as Callie Torres' father, for a 'Callie-centric' episode that would air mid-November.

Scorsone was a regular on the Grey's Anatomy spin-off, Private Practice, where she also portrayed Amelia Shepherd.

[46] On May 2, 2014, it was announced that the rest of the 6 original castmates, Justin Chambers, Chandra Wilson, and James Pickens Jr., excluding Sandra Oh, had renewed their contracts for another 2 seasons (11 and 12).

Annie Barett of Entertainment Weekly gave a positive review to the season and wrote, "There's true sorrow here along with the passion, which keeps their dynamic so intriguing to me.

Club also praised the tenth season of the show stating, "At its best, Grey's Anatomy is about everyday bravery, sacrifice, and courage.

"[96] The Loop also acknowledged the return to form giving a positive review, "After a shaky start to its tenth season, Grey's Anatomy has picked up the pace over the past 2 episodes and is once again showing a great deal of promise that it can revive itself after nearly a decade on the air.

"[97] Many sources, including Rachel Simon of Bustle and Nicole Pomarico of Wetpaint, claimed that Sandra Oh's performance during her tenth and final season on Grey's Anatomy is worthy of an Emmy nomination.

Simon stated "She made us care about Grey’s in a way we hadn’t in years, bringing us into Cristina’s life and mind, fully and ferociously.