Grillon (French pronunciation: [ɡʁijɔ̃]; Occitan: Grilhon) is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in southeastern France.

It lies approximately 6 kilometres (4 miles) from the Château and village of Grignan.

Grillon is twinned with Ano Syros, Greece.

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