The Gießen–Grünberg section was opened on 2 December 1869 by the Upper Hessian Railway Company (Oberhessische Eisenbahn-Gesellschaft).

The entrance building was built in Heimatstil (literally "home-style", related to the Swiss chalet style) and is now protected as a cultural monument under the Hessian Monument Protection Act (Hessisches Denkmalschutzgesetz) for historical and urban reasons.

[4] During an air raid on Großen-Buseck station on 18 March 1945, a construction train carrying forced labourers was hit.

It has a train dispatcher who operates the level crossing barriers and blocks passenger access to the island platform depending on the traffic situation.

[5] Großen-Buseck is connected by the bus network of the Rhein-Main-Verkehrsverbund: GI-25 to Gießen, GI-27 to Fernwald, GI-26 to Reiskirchen and GI-25 to Grünberg.