Group transfer reaction

[2] Group transfer reactions have diverse applications in various fields, including protein adenylation, biocatalytic and chemoenzymatic approaches for chemical synthesis, and strengthening skim natural rubber latex.

Along with a preference for reducing the least conjugated double bond, showcasing the precision of reductions with diimides in targeted organic synthesis.

The capacity of ene reduction to catalyze diverse reactions with high selectivity renders it a valuable tool in the synthesis of complex and stereospecific compounds.

Ene reduction plays a role in the production of fine chemicals, pharmaceutical compounds, agrochemicals, and biofuels.

Highlighting the functionality of ene reductases emphasizes their crucial role in catalyzing a variety of reactions.

Figure 1 . The mechanism of the group transfer reaction is allowed by the orbital overlap of the HOMO of the ene and the LUMO of the enophile.
Figure 2 . Generic ene reaction.
Figure 3. Generic mechanism of a reduction with diimide adapted from Mandal [ 9 ] .
Figure 4 . Scheme of protein adenylylation of threonine and tyrosine side chains, a biological application of group transfer reactions. This figure is adapted from Hedberg and Itzen. [ 4 ]
Figure 5. The ene reduction of an alkene using OYE2 ene reductase. This figure is adapted from an article on the Discovery, Characterization, Engineering, and Applications of Ene-Reductases for Industrial Biocatalysis [ 5 ] .