277814683ENSG00000087460ENSMUSG00000027523O95467P63092P84996Q5JWF2P63094Q6R0H7Q9Z0F1Q6R0H6NM_001309842NM_001309861NM_001309883NM_016592NM_080425NM_080426NM_022000NM_201616NM_201617NM_201618NM_001310083NM_001310085NM_001364030NP_001296771NP_001296790NP_001296812NP_057676NP_536350NP_536351NP_000507.1NP_001070956.1NP_001070957.1NP_001070958.1NP_001296769.1NP_536350.2NP_536351.1NP_001070958.1NP_001296812.1NP_001296812.1NP_536350.2NP_062664NP_068840NP_963910NP_963911NP_963912NP_001350959NP_001070975.1NP_001297014.1NP_034439.2NP_963911.1NP_062664.2NP_068840.2NP_001070975.1NP_001297014.1NP_963911.1NP_963912.1The Gs alpha subunit (Gαs, Gsα) is a subunit of the heterotrimeric G protein Gs that stimulates the cAMP-dependent pathway by activating adenylyl cyclase.

[6][7] When not stimulated by a receptor, Gα is bound to GDP and to Gβγ to form the inactive G protein trimer.

[6][7] When the receptor binds an activating ligand outside the cell (such as a hormone or neurotransmitter), the activated receptor acts as a guanine nucleotide exchange factor to promote GDP release from and GTP binding to Gα, which drives dissociation of GTP-bound Gα from Gβγ.

[6][7] In particular, GTP-bound, activated Gsα binds to adenylyl cyclase to produce the second messenger cAMP, which in turn activates the cAMP-dependent protein kinase (also called Protein Kinase A or PKA).

[8] The G protein-coupled receptors that couple to the Gs family proteins include: