Part of the Agew Awi Zone, Guangua is bordered on the south and west by the Benishangul-Gumuz Region, on the north by Dangila, on the northwest by Faggeta Lekoma and Banja Shekudad, and on the east by Ankasha Guagusa; the Dura River, a tributary of the Abay River, defines part of its western border.

The administrative center of this woreda is Chagni; other towns in Guangua include Kilaj, and Menta Wuha.

High points in this woreda include Mount Gum (1506 meters), which R E Cheesman described as a prominent landmark near the Zakas ford on the Abay.

[3] Originally the two adjacent woredas in the Benishangul-Gumuz Region, Dibate and Mandura, were subunits of Guangua but in the 1960s were split off to form separate woredas in order to strengthen government control over the local Gumuz people.

[4] Based on the 2007 national census conducted by the Central Statistical Agency of Ethiopia (CSA), this woreda has a total population of 223,066, an increase of 51.10% over the 1994 census, of whom 111,172 are men and 111,894 women; 31,489 or 14.12% are urban inhabitants.