Guaniguanico, also known as Cordillera de Guaniguanico, is a mountain range of western Cuba that extends from the centre-west of Pinar del Río Province to the western area of Artemisa Province.

[2] Granberry and Vescelius (2004) suggest a Guanahatabey etymology for the name Guaniguanico, comparing it with wani-wani-ku 'hidden moon, moon-set' in the purportedly related Warao language of the Orinoco Delta.

The two subranges composing it, Sierra de los Órganos (west) and Sierra del Rosario (east), are divided in the middle by the San Diego River (Río San Diego).

The highest peak is the Pan de Guajaibón (699 m), located between the municipalities of Bahía Honda and La Palma.

[2][4] The Guaniguanico includes the Viñales Valley,[5] a natural reserve and World Heritage Site; and other landmarks as the waterfalls of Salto de Soroa, the nature reserve of Las Terrazas, and the protected area of Mil Cumbres.