Guildford entered the Register of Shipping in 1810 with Johnson, master, Mangles, owner, and trade London—Jamaica.

On 4 July 1811 he received a letter of marque, which authorised Guildford, while under his command, to engage in offensive, and not just defensive, action against the French.

[3] On her first convict voyage, Guildford left London on 3 September 1811 in company with General Graham.

She reached Rio de Janeiro on 27 October,[1] and arrived at Port Jackson on 18 January 1812.

[12] On her fifth convict voyage, Guildford left London on 7 April 1822, arrived at Port Jackson on 15 July.

[14] On her sixth convict voyage, Guildford left Portsmouth on 18 August 1823, and arrived at Port Jackson on 5 March 1824.

On her return voyage she reached Madras on 11 January 1826 and St Helena on 23 March, and arrived at the Downs on 30 May.

[1] For her seventh convict voyage, Mangles and the EIC agreed a freight rate of £10 10s for Guildford to bring home teas from China.

For her homeward voyage for the EIC she crossed the Second Bar, about 20 miles (32 km) downriver from Whampoa, on 5 December, reached St Helena on 18 February 1828, and arrived at the Downs on 12 April.

[19] Under the command of Robert Harrison, Guildford left Dublin, Ireland on 12 July 1829, on her eighth convict voyage.

[22] She was wrecked in the Indian Ocean (approximately 7°N 80°E / 7°N 80°E / 7; 80) in late April or early May 1831 with the ultimate loss of all on board.