Guilford is a town in Chenango County, New York, United States.

One of the first settlements was in what is now known as East Guilford, by the Mercereau brothers (who were Revolutionary War spies for George Washington).

They built a mill on Guilford Creek at Indian Orchard Falls, along the Catskill Turnpike.

The town was called by an older name, "Fayette", for the early part of its history during the time it was in Tioga County.

New York State Route 8 is a north–south highway paralleling the Unadilla River.

22.7% of all households were made up of individuals, and 9.9% had someone living alone who was 65 years of age or older.