[6] In his business activity, the export of cut flowers stands out since 1979, as well as the presidency for 10 years until 2003, of a company dedicated to the storage, handling and custody of merchandise associated with logistics processes.

[3] Since November 2003, he has held the presidency of FENALCO (National Federation of Merchants), an entity to which he has been linked as a member of its board of directors on different occasions since 1985.

[9] Within the framework of his duties, Botero has controversially confronted the rearmament of former FARC leaders;[10] the proposal to regulate social protest as a result of the constant marches against the government;[11] the scandal of the false evidence presented by President Duque before the General Assembly of the United Nations denouncing the guerrilla incursion into Venezuela and the support of the president of that country, Nicolás Maduro for these groups in September 2019,[12] as well as the denunciations of the so-called false positives scandal.

[15][16] Before the second motion was voted on, Botero announced his resignation on 6 November 2019, one day before it began, after immense citizen pressure caused by various events presented in his mandate, such as the murder of Dimar Torres (which raised suspicions of the return of extrajudicial executions, popularly known as "false positives").

[17] After resigning from his position as defense minister, on February 23, 2021, Botero was appointed by President Iván Duque as Ambassador of Colombia to the Republic of Chile.