Guy Self is a fictional character from the BBC medical drama Holby City played by John Michie.

On 12 July 2013, it was announced that actor John Michie had joined the cast of Holby City as new consultant neurosurgeon Guy Self.

[3] The actor told a reporter for the BBC that he spent some time observing the consultant's demeanour, which was "friendly and chatty, but with an unspoken authority".

He is a spontaneous, original thinker who seldom lets rules dictate his lust for work and life.In an interview published on BBC Online, Michie explained that Guy is committed to being a neurosurgeon, which makes him ruthless at times.

[3] In August 2016, Guy's mother Valerie Sturgeon (Brigit Forsyth) was introduced, leading to further exploration of the character's background.

The actor told Inside Soap's Laura-Jayne Tyler, "Hopefully people will have more sympathy for him, rather than see him as a total bastard!

"[5] When Guy's mother Valerie is admitted to Darwin, she meets her granddaughter Zosia March (Camilla Arfwedson) for the first time.

[5] Michie said filming the scenes with Arfwedson was "a little bit disturbing", as he had to find something in his personal life that made him feel the same as his character.

[6] Michie told Allison Jones of Inside Soap, "Guy is very vulnerable, like a cornered animal, and he isn't really thinking straight.

"[6] Michie found it sad saying goodbye to the show and his co-stars, but he added that it was also an exciting time, as he liked moving on to new roles.

[9] Guy returns alongside Mo Effanga (Chizzy Akudolu) in the twentieth series episode "One of Us", broadcast on 20 November 2018.

[11] Executive producer Simon Harper expressed his joy at the character's return, calling Guy "oily" and "Holby's very own neurological Lord of Misrule, who is always guaranteed to sow trouble and strife".

[11] Harper also revealed that Guy would clash with Ric, which would create friction on the Acute Assessment Unit (AAU).

[11] Holby City was cancelled in June 2021 after 23 years on air with the final episode due to be broadcast in March 2022.

[13] Commenting on Michie's casting straight after his role in Coronation Street, a reporter for the Belfast Telegraph thought producers had made it difficult for them and some viewers to continue watching.