Guyana competed at the 2019 Pan American Games in Lima, Peru from July 26 to August 11, 2019.

[1][2] On July 14, 2019 the Guyana Olympic Association announced the full team of 26 athletes (17 men and nine women) competing in eight sports.

[3] During the opening ceremony of the games, boxer Keevin Allicock carried the flag of the country as part of the parade of nations.

[12][13][14][15] Guyana qualified a men's team of 12 athletes, by finishing as runner ups at the 2018 RAN Sevens.

[3] Guyana received two universality spots in swimming to enter one man and one woman.