Pymatuning South is a census-designated place (CDP) in Crawford County, Pennsylvania, United States.

[3] As of the census[6] of 2000, there were 467 people, 199 households, and 131 families residing in the CDP.

There were 342 housing units at an average density of 134.1 per square mile (51.8/km2).

The racial makeup of the CDP was 98.93% White, 0.64% Native American, 0.21% Asian, and 0.21% from two or more races.

29.1% of all households were made up of individuals, and 12.6% had someone living alone who was 65 years of age or older.