DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.
The table above describes the efficiency of serological typing of DR12 and DR5.
DR12 is associated with vulval lichen sclerosus,[3] and undifferentiated spondyloarthritis.
[4] DRB1*1201 is associated with iritis in juvenile arthritis,[5] primary antiphospholipid syndrome,[6] tiopronin intolerance in rheumatoid arthritis,[7] adult chronic articular Still's disease[8] DRB1*1202 is found to be increased in narcolepsy associated sudden death syndrome in the Thai population,[9] and narcolepsy in the Japanese population.
DRB1*12:DQA1*0505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a transhaplotype risk for coeliac disease[10] DRB1*1201:DRB3*01/03: colorectal cancer[11] HLA-DR12 is genetically linked to DR52[12] and HLA-DQ7 serotypes.