HLA-DR5

HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.

Except for a few DRB1* alleles, the reactivity of DR5 is relatively poor.

DR5 is associated with persistent generalized lymphadenopathy[3] and Kaposi's sarcoma in AIDS,[4] juvenile rheumatoid arthritis,[5][6] pernicious anemia, Hashimoto's thyroiditis,[7][8] mycosis fungoides,[9] polyglandular deficiency syndrome,[10] systemic sclerosis,[11][12] childhood epilepsy,[13] early-onset alopecia areata,[14] short-ragweed Ra6 allergy,[15] primary antiphospholipid syndrome,[16] and increased longevity in the Dutch.

[17] HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52).