HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus.
Three allele groups can produce 35 isoforms.
DRB3, DRB4, and DRB5 are minor DR beta-encoding loci, and they have been recognized as having distinct evolution,[1] having diverged from DRB1 around 4 million years ago.
[2] The DRB3 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.
DR52 serotype is positively associated with systemic sclerosis,[4] inflammatory myopathies,[5] inclusion body myositis,[6] DRB3*01 is positively associated with sarcoidosis,[7] Grave's Disease,[8][9] pulmonary sarcoidosis,[10] DRB3*01:01:DRB1*03:01 is linked to Lofgren's syndrome[11] DRB3*02:02 is also linked to Grave's disease,[9] serum IgG antibodies to Chlamydia pneumoniae with essential hypertension,[12] acute necrotizing encephalopathy[13] DRB3*03:01 is weakly associated with anticardiolipin antibodies in SLE[14] DRB3*03:01:DRB1*13:02 may be associated with Crohn's disease[15] HLA-DRB3 is linked to these HLA-DR serotypes and DRB1 allele groups: