HOT-17 (2,5-dimethoxy-4-(β-isobutylthio)-N-hydroxyphenethylamine) is a psychedelic phenethylamine of the 2C family.

It was synthesized by Alexander Shulgin and reported in his book PiHKAL.

It has structural properties similar to 2C-T-17 and to other drugs in the HOT- series, with the most closely related compounds being HOT-2 and HOT-7.

The dosage range of HOT-17 is typically 70-120 mg and its duration is approximately 12–18 hours according to Shulgin.

[1] HOT-17 produces time distortion and general psychedelia.