[5][6][7] In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes.

Expression of these proteins is spatially and temporally regulated during embryonic development.

This gene is involved in the regulation of uterine development and is required for female fertility.

Mutations in this gene can cause radioulnar synostosis with amegakaryocytic thrombocytopenia.

[7] This article incorporates text from the United States National Library of Medicine, which is in the public domain.