The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.

Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem.

The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation.

[6] This article on a gene on human chromosome 12 is a stub.

You can help Wikipedia by expanding it.This article incorporates text from the United States National Library of Medicine, which is in the public domain.