Downregulation of this gene’s isoforms could potentially lead to less proliferation of certain cancerous cells.

With the HOXC6-1 isoform, there were no statistically significant effects on migration, invasion, apoptosis, or proliferation when it was downregulated.

[10] According to a study in Cancer Cell International, suppression of the HOXC6 gene plays a role in blocking the TGF-β/SMAD cascade.

This then leads to the weakening of epithelial to mesenchymal transition for the cervical carcinoma.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.