It is included in a cluster of homeobox D genes located on chromosome 2.

The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development.

Mutations in this gene have been associated with Wilms' tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.

[5][citation needed] The HOXD10 gene is repressed by the microRNAs miR-10a and miR-10b.

[6][7][8] This article incorporates text from the United States National Library of Medicine, which is in the public domain.