Hamer's General Store was a small commercial building on the eastern side of the village of Mechanicsburg, Ohio, United States.

[3] Hamer's General Store was a weatherboarded building with a brick foundation, elements of stone and metal,[4] and a composite roof rising to a gable.

[3] In 1985, Hamer's General Store was listed on the National Register of Historic Places, qualifying as a rare surviving example of late-nineteenth-century commercial architecture.

It was part of a multiple property submission of approximately twenty buildings,[1] scattered throughout the village in such a low concentration that a historic district designation was not practical.

[2]: 8  Despite this designation, Hamer's is no longer standing; a Valero gas station occupies the site where the store was once located.