[1] Morris's interest in psychoactive substances blossomed in his late teens when he began reading pharmacology information hosted on websites such as Bluelight and Erowid.

[9][10] Vice later hired him to write a monthly print column titled "Hamilton's Pharmacopeia" in 2009 that evolved into a series of articles and documentaries for VBS.tv focused on the science of psychoactive drugs.

[11] Morris frequently consults with media on the subject of psychoactive drugs and conducts pharmacological research at Saint Joseph's University in Philadelphia[3][12][13] with an emphasis on the synthesis and history of dissociative anesthetics.

[2] In October 2021, it was reported that Morris was working as a chemist in Jason Wallach's lab at the University of the Sciences's Philadelphia College of Pharmacy.

[18] Morris has coauthored scientific papers on hallucinogens with Wallach, including a 2014 review on dissociatives[14] and a 2023 study identifying serotonergic psychedelics as mediating hallucinogenic-like effects (i.e., the head-twitch response) via activation of the serotonin 5-HT2A receptor Gq signaling pathway.