It was not as successful as some of Gross's earlier works, notably his book Nize Baby (1926) based on his newspaper comic strips.

After a chain of humorous occurrences (presented primarily as slapstick comedy) the protagonist is reunited with his love and discovers that he is the son of a rich industrialist.

Gross's characteristic artwork precedes other similar cartoonish styles, such as that of Harvey Kurtzman of MAD Magazine.

The layout of panels in He Done Her Wrong appears generally standard, but Gross employs several creative framing techniques.

His simplistic art style in He Done Her Wrong, while perhaps not as striking as the contemporary woodcut works that influenced it, nonetheless succeeds in producing recognizable characters without identifying them by name.

Later comics works, especially graphic novels, often rely heavily on specific orientation of panels to achieve a desired effect or style of reading, a technique which is visible in the fluid and progressive layout of He Done Her Wrong.