The Health District has the country's largest concentration of medical and research facilities after Houston.

The neighborhood has its roots as a health district with the opening of Jackson Memorial Hospital in 1915, with some of the original buildings, such as The Alamo still standing.

[5] The Health District is the center of Miami's medical, research and biotechnology industries, and as such is home to many of the city's largest hospital systems.

[6] Some of the research institutes in the Health District are:[7] Civic Center is served by Metrobus throughout the area, and by the Miami Metrorail at: The Health District is served by Civic Center station, a station of the Metrorail rapid transit system.

In March 2012, the new Miami Trolley system inaugurated its first route which passes through Civic Center on its way to Marlins Park.