Heck's disease

Heck's disease, also known as Focal Epithelial Hyperplasia, is an asymptomatic, benign neoplastic condition characterized by multiple white to pinkish papules that occur diffusely in the oral cavity.

[1][2]: 411  It can present with slightly pale, smooth or roughened surface morphology.

[3] It exhibits surface cells with vacuolated cytoplasm around irregular, pyknotic nuclei and occasional cells with mitosis-like changes within otherwise mature and well-differentiated epithelium.

A distinguishing histologic feature is elongated rete ridges with mitosoid bodies.

[5] Possible treatment may be excisional biopsy for lesions of functional or aesthetic concern.