Helena is an unincorporated community and census-designated place (CDP) in Jackson County, Mississippi, United States.

[3] Helena is in eastern Jackson County, east of Escatawpa and north of Moss Point.

According to the United States Census Bureau, the Helena CDP has a total area of 4.2 square miles (10.8 km2), all land.

There were 280 housing units at an average density of 138.7 per square mile (53.6/km2).

14.3% of all households were made up of individuals, and 4.5% had someone living alone who was 65 years of age or older.