Vancleave is an unincorporated community and census-designated place (CDP) in Jackson County, Mississippi, United States.

[2] The original hamlet of Vancleave is along Mississippi Highway 57 on high ground north of the valley of Bluff Creek.

The CDP limits extend north as far as Mississippi Highway 614 (Wade–Vancleave Road), east to the Pascagoula River and Ward Bayou, and south to the Gautier city line at the mouth of Bluff Creek.

As of the 2020 United States census, there were 5,592 people, 1,785 households, and 1,224 families residing in the CDP.

The Jackson County Sheriff's Office provides law enforcement services for the community.

Vancleave is also home to a branch of the Jackson-George Regional Library, located at 12604 Highway 57.