Henry Lott Brook is a tributary of Mehoopany Creek in Wyoming County, Pennsylvania, in the United States.

[1] Henry Lott Brook joins Mehoopany Creek 12.02 miles (19.34 km) upstream of its mouth.

[2] The elevation near the mouth of Henry Lott Brook is 1,070 feet (330 m) above sea level.

[5] Coal deposits were rumored to be present at the headwaters of Henry Lott Brook in the late 1800s.

[2] Wild trout naturally reproduce in Henry Lott Brook from its headwaters downstream to its mouth.

[6] Henry Lott Brook was entered into the Geographic Names Information System on August 2, 1979.