[11] This gene plays a pivotal role in the expression and synthesis of SHBG, an important glycoprotein made primarily in the liver,[12] which in addition to lowering insulin-resistance also reduces levels of free Estrogen as-well as prolonging the half-life of testosterone.

[citation needed] Function of HNF4A gene can be effectively examined by siRNA knockdown based on an independent validation.

[15] Increased amplification of hepatocyte nuclear factor 4 alpha has been observed in colorectal cancer.

[16] It has also associations with the appearance of Fanconi syndrome phenotypes which occurs due to a missense mutation of the gene.

[17] Hepatocyte nuclear factor 4 alpha has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.