[3] Following the end of Solá's administration in 2007, Lorenzino was appointed Financial Representative for Argentina in Washington, D.C.[1] The resignation of Economy Minister Martín Lousteau amid the 2008 Argentine government conflict with the agricultural sector in April, led to Lorenzino's appointment as Secretary of Finance for the new Economy Minister, the more conciliatory Carlos Rafael Fernández.

[6] Lorenzino also served in La graN maKro, a center-left economic and social policy think tank closely allied with Kirchnerism.

Lorenzino was, moreover, the most pragmatic major official in Boudou's team with regards to the international bond market and the Paris Club of creditors,[3] and the Minister-designate subsequently announced that debt restructuring would be acquire a greater policy relevance during his tenure.

[7] An April 2013 interview by Greek journalist Eleni Varvitsioti resulted in a stir when Lorenzino refused to answer a question regarding Argentine inflation; unbeknownst to him, the microphones were left on and recorded him saying me quiero ir ("I want to leave").

[12] Lorenzino's tenure was marked by ongoing efforts to counter vulture fund lawsuits to obtain payment at face value on nearly USD1.5 billion of bonds bought for pennies on the dollar.