In the mid 19th century the citizens of Oberamt Herrenberg (one of the former districts of Baden-Württemberg, that were replaced in 1934 by Landkreise) were mostly engaged in agriculture.

In the 1860s, Herrenberg sought a connection to the rail network so that and the district could have access to night soil from the latrines of Stuttgart as cheap fertilizer in order to grow produce for supply to the Böblingen sugar beet factory and the breweries.

But because of the difficult geographical conditions, the parliament of Württemberg voted not to require the Royal Württemberg State Railways to build the connection sought from Stuttgart via the western Filder plain and the Korngäu district of the northern Black Forest.

Funding of this work involved the city of Herrenberg and the surrounding communities of Kuppingen, Oberjettingen, Unterjettingen and Affstätt, whose inhabitants still hoped to have their own stations.

As a new junction, it received several new tracks, a signal box, a locomotive shed with a turntable and a water tower.

On 6 December 1992, the station was connected to the Stuttgart S-Bahn network with extension of line S 1, which had earlier ended in Böblingen.