It flows southeast for a short distance before turning east-southeast and entering a valley.

It then continues in the same direction for a short distance before reaching its confluence with the Susquehanna River.

[1] Herrold Run joins the Susquehanna River 111.24 miles (179.02 km) upstream of its mouth.

[6] Herrold Run was entered into the Geographic Names Information System on August 2, 1979.

[3] This variant name appears in a United States Geological Survey map.

[4] In May 2011, a $243,451 project to replace a bridge over Herrold Run with a box culvert and improve the adjacent road was begun.

[8] On July 7, 2011, the Pennsylvania Department of Transportation issued a statement saying that it would open the bridge the next day.